Mechano-Hammett!

Congratulations to Meredith and co-workers on the publication of their paper “Substituent Effects and Mechanism in a Mechanochemical Reaction” in JACS!  The authors used single-molecule force spectroscopy to explore the force-coupled rates of the mechanically-driven spiropyran to merocyanine reaction and discovered a nice Hammett linear free energy relationship to help explain the results.